| Description | p40phox, also called Neutrophil cytosol factor 4 (NCF-4), is a cytosolic subunit of the phagocytic NADPH oxidase complex (also called Nox2 or gp91phox) which plays a crucial role in the cellular response to bacterial infection [ ]. NADPH oxidase catalyzes the transfer of electrons from NADPH to oxygen during phagocytosis forming superoxide and reactive oxygen species. p40phox positively regulates NADPH oxidase in both phosphatidylinositol-3-phosphate (PI3P)-dependent and PI3P-independent manner []. It contains an N-terminal PX domain, a central SH3 domain, and a C-terminal PB1 domain that interacts with p67phox []. The SH3 domain of p40phox binds to canonical polyproline and noncanonical motifs at the C terminus of p47phox [].This entry represents the SH3 domain of p40phox. | Name | Neutrophil cytosol factor P40, SH3 domain |
| Short Name | p40phox_SH3 | Type | Domain |
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