| Description | The N-terminal domain of V-set and Ig domain-containing 4 (VSIG4), also referred to as CRIg or Z39Ig, belongs to the IgV family of immunoglobulin-like domains [ ]. A predominant feature of most Ig domains is a disulfide bridge connecting the two β-sheets with a tryptophan residue packed against the disulfide bond [].V-set and Ig domain-containing 4 (VSIG4) is a strong negative regulator of T cell proliferation and IL-2 production [ ]. It also negatively regulates macrophage activation by activating the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, reduction in mitochondrial reactive oxygen species secretion, and macrophage inhibition []. | Name | VSIG4, immunoglobulin variable (IgV)-like domain |
| Short Name | VSIG4_IgV | Type | Domain |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
