| Description | IdeS from Streptococcus pyogenes, also known as Mac-1, is an endopeptidase with specificity for IgG [ ]. The bacterial protein Mac-1 adopts an α/β fold, with 14 β strands and 9 α helices. The N-terminal domain is made up predominantly of α helices, whereas the C-terminal domain consists predominantly of β sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity. | Name | Ig protease IdeS |
| Short Name | IdeS | Type | Domain |
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