| Description | Animal heme peroxidases of the dual-oxidase like subfamily play vital roles in the innate mucosal immunity of gut epithelia. They provide reactive oxygen species which help control infection [ , , , , ].One innate immune mechanism is ROS (reactive oxygen species) production by NADPH oxidases of the NOX/DUOX (NADPH oxidase/dual oxidase) family. NOX enzymes consist of one NADPH oxidase domain and most often produce O2- (superoxide). Dual oxidases (DUOX) are enzymes that contain an NADPH oxidase domain that produces hydrogen peroxide (H2O2) and a peroxidase domain that can utilize H2O2 to carry out a variety of reactions [ , ]. | Name | Dual oxidase, peroxidase domain |
| Short Name | DUOX_peroxidase | Type | Domain |
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