help  | faq  | software  | BAR

Protein Domain : IPR010227

Description  This entry contains members of the complex I subunit 4 family. Members of this family include the 13th structural gene, M, of bacterial NADH dehydrogenase I (based on Escherichia coli), as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex.NADH:ubiquinone oxidoreductase (complex I) ( ) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [ ]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [ ], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. Name  NADH-quinone oxidoreductase, chain M/4
Short Name  NADH_Q_OxRdtase_chainM/4 Type  Family
Quick Links:
 
Quick Links:
 

3 Publications

Genomics

1 Cross References

 

Other

1 Child Features

1 Data Sets

1 Parent Features

10 Protein Domain Regions