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Protein Domain : IPR000283

Description  NADH:ubiquinone oxidoreductase (complex I) ( ) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [ ]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [ ], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [].This entry represents the 75kDa subunit from NADH:ubiquinone oxidoreductase. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 75kDa (in mammals), which is the largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to two 4Fe-4S clusters (called N-3 and N-4). Name  NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Short Name  NADH_UbQ_OxRdtase_75kDa_su_CS Type  Conserved_site
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Genomics

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21 Protein Domain Regions