| Description | Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia [ ]. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressed aryl hydrocarbon receptor nuclear translocators (ARNTs).In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth [ ].This entry represents a domain found in HIF alpha subunits and endothelial PAS domain-containing protein 1 (HIF1-alpha-like). | Name | Hypoxia-inducible factor, alpha subunit-like |
| Short Name | HIF_alpha-like | Type | Domain |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
