| Description | Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. In the pyrimidine synthesis pathway, OPRT catalyses the reversible phosphoribosyl transfer from 5'-phospho-alpha-D-ribose 1'-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5'-monophosphate (OMP) [ ]. The structures and properties of the OPRTases from different species have been described in several publications [, , , ]. | Name | Orotate phosphoribosyltransferase |
| Short Name | OPRT | Type | Family |
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