| Description | This family is the long form of Glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme [ ].There are two forms of Glucose-1-phosphate thymidylyltransferase in bacteria and archeae, a short form (see ) and a long form. The homotetrameric short form is found in numerous bacterial species that incorporate dTDP-L-rhamnose, which it helps synthesize, into the cell wall. It is subject to feedback inhibition. The long form, in contrast, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknown pathways, and in which dTDP-L-rhamnose is not necessarily produced. The long from enzymes also have a left-handed parallel helix domain at the C terminus, whereas, the short form enzymes do not have this domain [ , , , , ]. | Name | Glucose-1-phosphate thymidylyltransferase, long form |
| Short Name | G1P_thy_trans_l | Type | Family |
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