| Description | Nitroreductases are flavin-associated oxidoreductase enzymes that reduce nitro substituents on aromatic rings. They can be divided in two functional classes. Type I nitroreductases are oxygen-insensitive, i.e. can generate nitroso, hydroxylamine and/or amine end-products in the presence of molecular oxygen, whereas type II nitroreductases are oxygen-sensitive and can only generate these products when oxygen is absent [ ].This family includes type I oxidoreductases such as NfsB from Escherichia coli [ ], RdxA and FrxA from Helicobacter pylori [], and FRase I in Vibrio fischeri [], which reduces FMN into FMNH2 as part of the bioluminescent reaction []. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs [, ]. | Name | Oxygen-insensitive NAD(P)H nitroreductase NfsB-like |
| Short Name | NfsB-like | Type | Domain |
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