| Description | In fission yeast, Nro1 is a positive regulator of the stability of Sre1N, the sterol regulatory element-binding protein, which is an ER membrane-bound transcription factor that controls adaptation to low oxygen-growth [ ]. In addition, the fission yeast Nro1 is a direct inhibitor of a protein that inhibits SreN1 degradation, Ofd1 (an oxoglutamate deoxygenase). The outcome of this reactivity is that Ofd1 acts as an oxygen sensor that regulates the binding of Nro1 to Ofd1 to control the stability of Sre1N [].This entry also represents ETT1, an Nro1 ortholog [ ]. ETT1 is required for correct translation termination and probably involved in regulation of hypoxic gene expression in association TPA1 []. It inhibits replication of Brome mosaic virus []. | Name | Negative regulator of Ofd1/Enhancer of translation termination 1 |
| Short Name | Nro1/ETT1 | Type | Family |
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