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Gene : BRX A. thaliana

DB identifier  ? AT1G31880 Secondary Identifier  ? locus:2034486
Name  ? BREVIS RADIX Brief Description  DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein
TAIR Computational Description  DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein;(source:Araport11)
TAIR Curator Summary  Belongs to five-member BRX gene family. Arabidopsis BRX genes share high levels of similarity among each others, with several conserved domains. The most distinct is BRX domain - highly conserved in all BRX genes among distantly related species. This protein-protein interaction domain is required and sufficient for BRX activity. BRX encodes a key regulator of cell proliferation and elongation in the root, which has been implicated in the brassinosteroid (BR) pathway as well as regulation of auxin-responsive gene expression. Also involved in cytokinin-mediated inhibition of lateral root initiation. A loss-of-function allele, named brx-2 in Rodrigues et al. (2009) Plant Physiol. but changed to brx-3 to resolve nomenclature conflict (Li et al. Planta 2009:229(3):593-603), shows enhanced response to ABA-mediated inhibition of root growth. Plasma-membrane-associated element of a molecular rheostat that modulates auxin flux through developing protophloem sieve elements (PPSEs) while interacting with PAX, thereby timing PPSE differentiation. Dampens PIN-mediated auxin efflux.
TAIR Short Description  DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein
TAIR Aliases  BRX, NLM9

10 Gene Rifs

Trail: Gene

1 Organism

Trail: Gene

27 Publications

Trail: Gene

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4743  
Location: Chr1:11445490-11450232

Gene models - BRX AT1G31880

? Gene models

Transcripts: 2  Exons: 13  Introns: 11 

Overlapping Features

? Genome features that overlap coordinates of this Gene

11 Child Features

Trail: Gene

1 Cross References

Trail: Gene

1 Downstream Intergenic Region

Trail: Gene

0 Located Features

1 Upstream Intergenic Region

Trail: Gene

Proteins

Curated comments from UniProt

Type Comment Proteins
BRX_ARATH developmental stage Ubiquitously expressed in early embryos and becomes restricted to the vasculature in the mature embryo and at later stages of development (PubMed:19465596). Expressed in roots developing protophloem, up to the end of the transition zone, as well as in the root tip meristem (PubMed:23569225).
BRX_ARATH function Acts as a regulator of cell proliferation and elongation in the root and shoot (PubMed:25049386, PubMed:28652362). Regulates roots architecture and primary root protophloem differentiation (PubMed:25049386, PubMed:28652362). BRX, BAM3, and CLE45 act together to regulate the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem (PubMed:23569225). Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.
A0A1P8AWZ2_ARATH BRX_ARATH similarity Belongs to the BRX family.
BRX_ARATH subcellular location The translocation to the nucleus depends on the auxin concentration. Polar localization at the plasma membrane, rootward oriented, in developing root protophloem cells (PubMed:28652362).
BRX_ARATH tissue specificity Expressed in the developing protophloem up to the elongation zone in root meristem of young seedlings, in the columella and the phloem vasculature throughout the root and in the phloem vasculature in the shoot (PubMed:23569225). Detected in the shoot meristem and in primordia. Low expression in stomata. Confined to sieve element precursor cells and to protophloem (PubMed:25049386).

2 Proteins

Trail: Gene

Function

Interactions

Interaction Network

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Expression

eFP Visualization

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Co-expression

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Data Source: ATTED-II
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LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

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9 Data Sets

Trail: Gene