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Gene : BRX A. thaliana

DB identifier	AT1G31880	Secondary Identifier	locus:2034486
Name	BREVIS RADIX	Brief Description	DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein

TAIR Computational Description	DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein;(source:Araport11)
TAIR Curator Summary	Belongs to five-member BRX gene family. Arabidopsis BRX genes share high levels of similarity among each others, with several conserved domains. The most distinct is BRX domain - highly conserved in all BRX genes among distantly related species. This protein-protein interaction domain is required and sufficient for BRX activity. BRX encodes a key regulator of cell proliferation and elongation in the root, which has been implicated in the brassinosteroid (BR) pathway as well as regulation of auxin-responsive gene expression. Also involved in cytokinin-mediated inhibition of lateral root initiation. A loss-of-function allele, named brx-2 in Rodrigues et al. (2009) Plant Physiol. but changed to brx-3 to resolve nomenclature conflict (Li et al. Planta 2009:229(3):593-603), shows enhanced response to ABA-mediated inhibition of root growth. Plasma-membrane-associated element of a molecular rheostat that modulates auxin flux through developing protophloem sieve elements (PPSEs) while interacting with PAX, thereby timing PPSE differentiation. Dampens PIN-mediated auxin efflux.
TAIR Short Description	DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein
TAIR Aliases	BRX, NLM9

10 Gene Rifs

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1 Organism

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27 Publications

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0 Synonyms

Genomics

Genome feature

Region:	gene	Length:	4743
Location:	Chr1:11445490-11450232

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11 Child Features

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1 Cross References

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1 Downstream Intergenic Region

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0 Located Features

1 Upstream Intergenic Region

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Proteins

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Curated comments from UniProt

Type	Comment	Proteins
BRX_ARATH	developmental stage	Ubiquitously expressed in early embryos and becomes restricted to the vasculature in the mature embryo and at later stages of development (PubMed:19465596). Expressed in roots developing protophloem, up to the end of the transition zone, as well as in the root tip meristem (PubMed:23569225).
BRX_ARATH	function	Acts as a regulator of cell proliferation and elongation in the root and shoot (PubMed:25049386, PubMed:28652362). Regulates roots architecture and primary root protophloem differentiation (PubMed:25049386, PubMed:28652362). BRX, BAM3, and CLE45 act together to regulate the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem (PubMed:23569225). Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.
A0A1P8AWZ2_ARATH BRX_ARATH	similarity	Belongs to the BRX family.
BRX_ARATH	subcellular location	The translocation to the nucleus depends on the auxin concentration. Polar localization at the plasma membrane, rootward oriented, in developing root protophloem cells (PubMed:28652362).
BRX_ARATH	tissue specificity	Expressed in the developing protophloem up to the elongation zone in root meristem of young seedlings, in the columella and the phloem vasculature throughout the root and in the phloem vasculature in the shoot (PubMed:23569225). Detected in the shoot meristem and in primordia. Low expression in stomata. Confined to sieve element precursor cells and to protophloem (PubMed:25049386).

2 Proteins

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Function

Gene Ontology

cellular component
plasma membrane	ECO
nucleus	ECO
molecular function
identical protein binding	ECO
biological process
cell differentiation	ECO
root development	ECO
response to abscisic acid	ECO
regulation of root development	ECO
auxin export across the plasma membrane	ECO
maintenance of root meristem identity	ECO
sieve cell differentiation	ECO
lateral root development	ECO
auxin-activated signaling pathway	ECO
cytokinin-activated signaling pathway	ECO
phloem development	ECO

Interactions

Interaction Network

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Expression

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BAR Webservices

Querying ATTED Service... Data Source: ATTED-II

Homology

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9 Data Sets

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