| Description | This family of proteins includes components of the T cell receptor (TR) complex, which are crucial for the adaptive immune response. Members of this family are involved in recognizing peptide-major histocompatibility (MH) complexes displayed by antigen-presenting cells, a key step for T cell-mediated immunity against pathogens. Upon binding to these complexes, the TR proteins initiate a cascade of intracellular signaling events that lead to T cell activation and differentiation. This signaling involves the phosphorylation of immune receptor tyrosine-based activation motifs (ITAMs) and the formation of the LAT signalosome, which further propagates the signal to activate pathways such as calcium, MAPK kinase, and NF-kappa-B. These pathways are essential for gene expression, T cell growth, and differentiation. The T cell repertoire is generated through V-(D)-J rearrangement in the thymus and is shaped by selection events to produce a pool of self-MH restricted, non-autoaggressive T cells. The interaction of TR with peptide-MH complexes post-thymus also influences the structural and functional avidity of the T cell receptor. | Name | T cell receptor complex component |
| Short Name | TCR_complex_component | Type | Family |
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