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Interaction Term : MI:0031 protein cross-linking with a bifunctional reagent PSI Molecular Interactions

Description  Cross-linking agents induce the formation of covalent bonds among proteins that are neighbours. The cross-linker may be a bifunctional molecule having two reactive ends linked by a spacer, often containing a disulfide bond. When a reducing agent is added the disulfide bridge is cleaved, the cross-linked pairs are released and can be identified. There are various classes of cross-linkers, the most common are those having photoreactive groups that become reactive fluorophores when activated by UV light thereby resulting in photolabeling the cross-linked moieties. Namespace  PSI-MI
Obsolete  false

1 Data Sets

1 Ontology

6 Parents

5 Relations

3 Synonyms