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Protein Domain : IPR044748

Description  This entry represents the C-terminal methyltransferase domain of TARBP1 and Trm3 [ ].Yeast tRNA (guanosine(18)-2'-O)-methyltransferase Trm3 catalyses the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs []. Trm3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation [, ]. Name  Trm3/ TARBP1, C-terminal
Short Name  Trm3/TARBP1_C Type  Domain
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Genomics

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1 Data Sets

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7 Protein Domain Regions