| Description | This family of proteins is involved in the CRISPR adaptive immune system, which provides defense against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of this family are CRISPR-associated endoribonucleases known as Cas13a, which target and cleave RNA. They process pre-CRISPR RNA (crRNA) and are responsible for the cleavage of target single-stranded RNA (ssRNA) in a crRNA-dependent manner. Activation of these proteins for non-specific RNA degradation, also known as collateral RNA degradation, is triggered by the binding of a viable target RNA. The proteins contain two HEPN-like folds that interact to form the active site for RNA cleavage, and they undergo conformational changes upon RNA binding that are critical for their function. | Name | CRISPR-associated endoribonuclease Cas13a |
| Short Name | Cas13a_endoribonuclease | Type | Family |
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