| Description | This entry represents a group of proteins from plants and lower eukaryotes that are related to the archaeal DNA/RNA-binding protein Alba, also called histone-like protein ( ), and its eukaryotic homologues RNase P/MRP subunits Pop7/Rpp20 ( ) and Rpp25. Members of this family are the uncharacterised protein At2g34160 from Arabidopsis thaliana, which affects rRNA processing [ ], and Endonuclease ALBA3 from Plasmodium falciparum, which can bind both DNA and RNA [, ].Structural comparisons have shown that Alba (Sso10b2 from the thermoacidophilic archaeon Sulfolobus solfataricus) is topologically similar to several RNA-binding proteins (or A-DNA-binding) and includes IF3-C, YhhP, and DNase I. All of them have a similar IF3-C fold [ , ] and it has been suggested that the ancestral function of the IF3-C fold is related to RNA interaction, and that the Alba superfamily proteins originated as RNA-binding proteins that formed various ribonucleoprotein complexes, probably including RNase P, and were then recruited as a chromosomal protein within the crenarchaeal lineage []. Based on this, it has been suggested that the archaeal Alba proteins () are involved in RNA binding as well as DNA binding [ , ], a prediction that has been confirmed experimentally [].For more information about Alba, please see . | Name | Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related |
| Short Name | UCP030333_Alba | Type | Family |
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