Description | While most bacteria synthesise lysine via diaminopimelate, a few species, such as Thermus thermophilus, and some hyperthermophilic archaea, synthesise this amino acid from alpha-aminoadipate (AAA). LysW plays an essential role in this pathway by preventing unstable intermediates from undergoing intramolecular cyclisation [ ]. This is accomplished by covalent binding of the reactive amino group of AAA to a glutamate residue in LysW. The covalently attached AAA is subsequently converted to lysine and then released from LysW by the action of other proteins in this pathway. | Name | Lysine biosynthesis protein LysW |
Short Name | LysW | Type | Family |