Description | Maspin (mammary serine proteinase inhibitor; Serpin B5; MEROPS identifier I04.980) is a non-inhibitory member of the serpin superfamily (clade B) [ , ], with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer [, , ].In general, SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms [ ]. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones []. | Name | Maspin, serpin domain |
Short Name | SERPINB5_serpin_dom | Type | Domain |