| Description | This entry represents a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains [ ]. This domain has been recently characterised in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS (cyclic oligonucleotide-based antiphage signaling system) immunity, a bacterial system that provides immunity against bacteriophage [, ]. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages []. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection. | Name | SMODS-associated and fused to various effectors |
| Short Name | SAVED | Type | Domain |
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