| Description | NLRC4 is a nucleotide binding/leucine-rich Repeat (NLR) protein and a inflammasome activator. It contains an N-terminal homotypic interaction domain, a central nucleotide binding domain, and a series of C-terminal LRRs. NLRC4 activates CASP1, the primary protease responsible for converting pro-IL-1beta to active, secreted IL-1beta. NLRC4 has been linked to autoinflammation diseases [ ]. | Name | NLR family CARD domain-containing protein 4 |
| Short Name | NLRC4 | Type | Family |
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