| Description | This entry includes a group of cyclic nucleotide phosphodiesterases, including GpdQ and CpdA. They belong to the metallophosphatase (MPP) superfamily.GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents []. The GpdQ homologue, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity [].CpdA hydrolyses cAMP to 5'-AMP. It plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes [ ]. In Pseudomonas is specifically required for regulation of virulence factors and can also hydrolyse cGMP []. | Name | Cyclic nucleotide phosphodiesterase GpdQ/CpdA-like |
| Short Name | GpdQ/CpdA-like | Type | Family |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
