Description | This domain consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence [ ] and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) []. | Name | Hepatocyte nuclear factor 1, N-terminal |
Short Name | HNF-1_N | Type | Domain |