| Description | This domain is found in CASC1 (cancer susceptibility candidate gene 1 protein) from humans and IC97 from Chlamydomonas [ ]. There are two completely conserved residues (N and W) that may be functionally important.Dynein-f, also known as dynein I1, is an inner-arm dynein complex comprising two different heavy chains together with a number of intermediate and light chains. In Chlamydomonas, IC97 is the intermediate chain of the Dynein-f complex. This entry includes IC97 ( ) and its homologues, including CASC1 (also known as Dnai7) from humans [ ].The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility [ ]. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene [ ]. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ]. | Name | IC97/Casc1, N-terminal |
| Short Name | IC97/Casc1_N | Type | Domain |
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