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Protein Domain : IPR053473

Description  This family of proteins is involved in bacterial cell wall biosynthesis. They possess a bifunctional mechanism with distinct domains responsible for different stages of peptidoglycan formation. The N-terminal domain functions as a transglycosylase/glycosyltransferase, which is not inhibited by penicillin and is responsible for the polymerization of glycan chains, forming linear strands of peptidoglycan. The C-terminal domain exhibits transpeptidase activity, which is sensitive to penicillin and is crucial for cross-linking peptide subunits in the cell wall. The proteins are known to bind lipid II intermediates and are capable of hydrolyzing thiolester analogs of cell wall precursors. Their activity is influenced by various factors, including the presence of detergents and antibiotics, with specific detergents enhancing or inhibiting their glycosyltransferase activity, and antibiotics like moenomycin and vancomycin affecting them differently. Name  Bacterial Cell Wall Biosynthesis Protein
Short Name  Cell_Wall_Biosynth_Protein Type  Family
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