| Description | This family includes FERM domain-containing protein 6 (FRMD6, also known as willin and hEx/human expanded), its homologue from Drosophila, Expanded (Ex) and FERM domain-containing protein 1 (FRMD1). Ex, is a regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a pivotal role in organ size control and is tumour suppression by restricting proliferation and promoting apoptosis [, ]. Human FRMD6 was first thought to function independently of the Hippo pathway as it lacks the C-terminal domain of Ex that allows it to directly interact with various downstream Hippo signalling components [, ]. However, it has been shown to act as an upstream regulator of Hippo signalling that modulates actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signalling []. FRMD6 is widely distributed in various tissues and cell types; in the nervous system is involved in neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. It has been implicated in the progression of Alzheimer's disease (AD) [] and positioned as a novel AD risk gene [].There is not much information about FRMD1 to date. Both FRMD1 and FRMD6 contain a single FERM domain, which is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. | Name | FERM domain-containing protein 6-like |
| Short Name | FRMD6-like | Type | Family |
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