| Description | 3,4-dihydroxyphenylacetate (homoprotocatechuate, hpca) 2,3-dioxygenase (HPCD) catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The enzyme incorporates both atoms of molecular oxygen into hpca, resulting in aromatic ring-opening to yield alpha-hydroxy-delta-carboxymethyl cis-muconic semialdehyde [ , ].HPCD is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. | Name | 3,4-dihydroxyphenylacetate 2,3-dioxygenase |
| Short Name | HPCD | Type | Family |
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