| Description | Protein wntless (WLS) regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism [ , , ]. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. It also plays also an important role in establishment of the anterior-posterior body axis formation during development []. This protein is homologous to GPR180, TMEM145, and TMEM181, which have been described as GOST proteins (for GOLD domain seven-transmembrane helix proteins) together with TMEM87A/B, GPR107, and GPR108, as they share the same domain architecture consisting of a GOLD domain atop of a membrane-spanning seven-transmembrane helix domain []. | Name | Protein wntless |
| Short Name | Wntless | Type | Family |
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