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Protein Domain : IPR045315

Description  This entry represents a group of mitochondrial carrier proteins, including Mtm1 from budding yeasts and SLC25A39/40 from humans. Mtm1 is a pyridoxal 5'-phosphate (PLP) transporter and is involved in mitochondrial iron homeostasis [ ]. SLC25A39 and its paralogue SLC25A40 are mitochondrial transporters essential for glutathione import into mitochondria, which is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis []. Knockdown of SLC25A39 in a zebrafish model has been shown to disrupt heme biosynthesis and results in profound anemia []. Name  Mitochondrial carrier protein Mtm1-like
Short Name  Mtm1-like Type  Family
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3 Publications

Genomics

1 Cross References

 

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0 Child Features

1 Data Sets

1 Parent Features

10 Protein Domain Regions