| Description | SPIN90, also known as NCK interacting protein with SH3 domain (NCKIPSD), is an F-actin binding protein that regulates actin polymerization and endocytosis [ ]. It associates with the Arp2/3 complex near actin filaments and determines filament localization at the leading edge of lamellipodia []. SPIN90 is expressed in the early stages of neuronal differentiation and plays a role in regulating growth cone dynamics and neurite outgrowth []. It also interacts with IRSp53 and regulates cell motility by playing a role in the formation of membrane protrusions []. SPIN90 contains an N-terminal SH3 domain, a proline-rich domain, and a C-terminal VCA (verprolin-homology and cofilin-like acidic) domain [].This entry represents the SH3 domain of SPIN90. | Name | SPIN90, SH3 domain |
| Short Name | SPIN90_SH3 | Type | Domain |
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