| Description | This entry represents an eukaryotic type I KH domain found in a group of proteins involved in pre-mRNA splicing, such as KH domain-containing BBP from fungi, KH homology domain-containing protein 4 (KHDC4, also known as BLOM7) and Splicing factor 1 from animals, animal quaking proteins such as human QKI, and homologues from plants, including RIK.BBP/SF1 family members include the branchpoint binding proteins (BBP) from yeast and their mammalian homologue, splicing factor 1 (SF1). They are required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [ , ]. BBP binds the conserved RNA sequence UACUAAC, called the branchpoint motif, found near the 3' end of yeast introns []. Besides its function in pre-mRNA splicing, BBP is also involved in nuclear retention of pre-mRNA []. Mammalian SF1, also known as ZFM1, may act as transcription repressor [].KHDC4 interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. It binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains [, ]. RIK1 interacts with rough sheath2 (RS2), which is a myb domain protein required to repress knox genes during leaf development [].Human QKI is involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development [ , , , ].The core KH domain is accompanied by additional α-helix and β-sheet motifs at the C terminus. | Name | KHDC4/BBP-like, KH-domain type I |
| Short Name | KH_1_KHDC4/BBP-like | Type | Domain |
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