| Description | This entry represents the conserved domain 1 (C1 domain) found in aPKC isoform zeta. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. Ιt contains two separate Zn(2)-binding sites.Protein kinases C (PKCs) are classified into three groups, classical, atypical (aPKCs), and novel, depending on their mode of activation and the structural characteristics of their regulatory domain [ ]. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota [, ]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [, , , ]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways [, , ]. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells [, ]. In addition, it affects actin remodelling in muscle cells [, ]. | Name | Protein kinase C zeta type, conserved region 1 |
| Short Name | C1_aPKC_zeta | Type | Domain |
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