DB identifier
|
AT5G56290 | Secondary Identifier
|
locus:2177606 |
| Name
|
peroxin 5 | Brief Description | peroxin 5 |
| TAIR Computational Description | peroxin 5;(source:Araport11) |
| TAIR Curator Summary | Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions. |
| TAIR Short Description | peroxin 5 |
| TAIR Aliases | ATPEX5, EMB2790, PEX5 |
Powered by
Have you tried our InterMine mobile apps?
and interoperation is funded by 
