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Gene : PFD3 A. thaliana

DB identifier  ? AT5G49510 Secondary Identifier  ? locus:2157819
Name  ? prefoldin 3 Brief Description  prefoldin 3
TAIR Computational Description  prefoldin 3;(source:Araport11)
TAIR Curator Summary  NULL
TAIR Short Description  prefoldin 3
TAIR Aliases  PFD3

0 Gene Rifs

1 Organism

14 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2443  
Location: Chr5:20080600-20083042

Gene models - PFD3 AT5G49510

? Gene models

Transcripts: 2  Exons: 13  Introns: 11 

Overlapping Features

? Genome features that overlap coordinates of this Gene

11 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
PFD3_ARATH function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it (PubMed:19825635). Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (PubMed:19825635). Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity). Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity (PubMed:19825635). Necessary for tolerance to NaCl salt stress (PubMed:19825635). Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus (By similarity). Prevents cold acclimation (e.g. 7 days at 4 degrees Celsius) in a DELLA proteins-dependent manner by promoting nuclear proteasome-mediated HY5 degradation, thus modulating the expression of several genes and reducing anthocyanin biosynthesis, but seems not involved in constitutive freezing tolerance (PubMed:28412546).
PFD3_ARATH similarity Belongs to the prefoldin subunit alpha family.
PFD3_ARATH subcellular location In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (PubMed:28412546). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (PubMed:28412546). This changing subcellular localization follows a daily rhythm coordinated oscillation (By similarity).

1 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
prefoldin complex  ? ECO  
polysome  ? ECO  
nucleus  ? ECO  
molecular function
tubulin binding  ? ECO  
biological process
cortical microtubule organization  ? ECO  
response to cold  ? ECO  
mRNA processing  ? ECO  
tubulin complex assembly  ? ECO  
protein folding  ? ECO  
cellular response to gibberellin stimulus  ? ECO  
microtubule-based process  ? ECO  
response to salt stress  ? ECO  
cold acclimation  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

8 Data Sets