Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
PFD3_ARATH | function | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it (PubMed:19825635). Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (PubMed:19825635). Together with other chaperonins, contribute to the regulation of gene expression by modulating the spliceosome function on pre-mRNA splicing post-transcriptionally by acting as a co-chaperone of Hsp90 to control levels of LSM8 (By similarity). Required for the biogenesis of tubulins and for subsequent microtubules (MTs) organization and dynamicity (PubMed:19825635). Necessary for tolerance to NaCl salt stress (PubMed:19825635). Involved in the process leading to microtubules dissociation in response to gibberellic acid (GA) probably due to the DELLA proteins-mediated translocation of the prefoldin co-chaperone complex from the cytoplasm to the nucleus (By similarity). Prevents cold acclimation (e.g. 7 days at 4 degrees Celsius) in a DELLA proteins-dependent manner by promoting nuclear proteasome-mediated HY5 degradation, thus modulating the expression of several genes and reducing anthocyanin biosynthesis, but seems not involved in constitutive freezing tolerance (PubMed:28412546). |
PFD3_ARATH | similarity | Belongs to the prefoldin subunit alpha family. |
PFD3_ARATH | subcellular location | In the presence of gibberellic acid (GA) and at room temperature, the prefoldin complex stays in the cytoplasm and is functional (PubMed:28412546). But in the absence of GA or in response to cold, the prefoldin complex is localized to the nucleus in the presence of DELLA proteins, which severely compromises alpha/beta-tubulin heterodimer availability, thus affecting microtubules (MTs) organization (PubMed:28412546). This changing subcellular localization follows a daily rhythm coordinated oscillation (By similarity). |
Function
Gene Ontology
cellular component | |
---|---|
cytoplasm | ECO |
prefoldin complex | ECO |
polysome | ECO |
nucleus | ECO |
molecular function | |
tubulin binding | ECO |
biological process | |
cortical microtubule organization | ECO |
response to cold | ECO |
mRNA processing | ECO |
tubulin complex assembly | ECO |
protein folding | ECO |
cellular response to gibberellin stimulus | ECO |
microtubule-based process | ECO |
response to salt stress | ECO |
cold acclimation | ECO |
Interactions
Interaction Network
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