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Gene : RPS4 A. thaliana

DB identifier  ? AT5G45250 Secondary Identifier  ? locus:2158475
Name  ? RESISTANT TO P. SYRINGAE 4 Brief Description  Disease resistance protein (TIR-NBS-LRR class) family
TAIR Computational Description  Disease resistance protein (TIR-NBS-LRR class) family;(source:Araport11)
TAIR Curator Summary  RPS4 belongs to the Toll/interleukin-1 receptor (TIR)-nucleotide binding site (NBS)-Leu-rich repeat (LRR) class of disease resistance (R ) genes. Confers specific resistance to Pseudomonas syringae pv. tomato carrying the avirulence gene AvrRPS4. Produces alternative transcripts with truncated open reading frames.
TAIR Short Description  Disease resistance protein (TIR-NBS-LRR class) family
TAIR Aliases  RPS4

14 Gene Rifs

1 Organism

54 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4412  
Location: Chr5:18321764-18326175 reverse strand

Gene models - RPS4 AT5G45250

? Gene models

Transcripts: 1  Exons: 5  Introns: 4 

Overlapping Features

? Genome features that overlap coordinates of this Gene

6 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
RPS4_ARATH function Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae (PubMed:10571887, PubMed:15469494, PubMed:19519800). Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein (PubMed:10571887, PubMed:15469494, PubMed:19519800). That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (PubMed:10571887, PubMed:15469494, PubMed:19519800). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792, PubMed:31439793). The combined presence of both regular and alternative RPS4 transcripts with truncated open reading frames (ORFs) is necessary for function (PubMed:17951452). RPS4 function is regulated at multiple levels, including gene expression, alternative splicing, and protein stability (PubMed:17951452). When over-expressed, confers temperature-conditioned EDS1-dependent auto-immunity (PubMed:24146667). Heterodimerization with RRS1 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Abscisic acid deficiency enhances nuclear accumulation of RPS4 and its cell death-inducing activity (PubMed:22454454).
RPS4_ARATH similarity Belongs to the disease resistance TIR-NB-LRR family.
RPS4_ARATH subcellular location Nuclear accumulation is necessary for triggering EDS1-dependent defense (PubMed:17997306). Found in microsomes when interacting with SRFR1 (PubMed:21079790). Accumulates in the cytoplasm and the nucleus, when associated with EDS1 (PubMed:22158818). Accumulates in nucleus at 22 degrees Celsius, but not at 28 degrees Celsius (PubMed:22454454).

1 Proteins

Function

Gene Ontology

cellular component
endomembrane system  ? ECO  
nucleus  ? ECO  
membrane  ? ECO  
cytoplasm  ? ECO  
molecular function
ATP binding  ? ECO  
NAD+ nucleotidase, cyclic ADP-ribose generating  ? ECO  
identical protein binding  ? ECO  
ADP binding  ? ECO  
NAD+ nucleosidase activity  ? ECO  
biological process
plant-type hypersensitive response  ? ECO  
defense response to bacterium  ? ECO  
innate immune response-activating signaling pathway  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets