Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
RPS4_ARATH | function | Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae (PubMed:10571887, PubMed:15469494, PubMed:19519800). Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein (PubMed:10571887, PubMed:15469494, PubMed:19519800). That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (PubMed:10571887, PubMed:15469494, PubMed:19519800). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792, PubMed:31439793). The combined presence of both regular and alternative RPS4 transcripts with truncated open reading frames (ORFs) is necessary for function (PubMed:17951452). RPS4 function is regulated at multiple levels, including gene expression, alternative splicing, and protein stability (PubMed:17951452). When over-expressed, confers temperature-conditioned EDS1-dependent auto-immunity (PubMed:24146667). Heterodimerization with RRS1 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Abscisic acid deficiency enhances nuclear accumulation of RPS4 and its cell death-inducing activity (PubMed:22454454). |
RPS4_ARATH | similarity | Belongs to the disease resistance TIR-NB-LRR family. |
RPS4_ARATH | subcellular location | Nuclear accumulation is necessary for triggering EDS1-dependent defense (PubMed:17997306). Found in microsomes when interacting with SRFR1 (PubMed:21079790). Accumulates in the cytoplasm and the nucleus, when associated with EDS1 (PubMed:22158818). Accumulates in nucleus at 22 degrees Celsius, but not at 28 degrees Celsius (PubMed:22454454). |
Function
Gene Ontology
cellular component | |
---|---|
endomembrane system | ECO |
nucleus | ECO |
membrane | ECO |
cytoplasm | ECO |
molecular function | |
ATP binding | ECO |
NAD+ nucleotidase, cyclic ADP-ribose generating | ECO |
identical protein binding | ECO |
ADP binding | ECO |
NAD+ nucleosidase activity | ECO |
biological process | |
plant-type hypersensitive response | ECO |
defense response to bacterium | ECO |
innate immune response-activating signaling pathway | ECO |
Interactions
Interaction Network
Show the following interaction types:
Reset view
Show in table format
Export graph
- Click on a gene to get more info about it.