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Gene : AT5G43560 A. thaliana

DB identifier  ? AT5G43560 Secondary Identifier  ? locus:2158387
Brief Description  TRAF-like superfamily protein
TAIR Computational Description  TRAF-like superfamily protein;(source:Araport11)
TAIR Curator Summary  Encodes MUSE14, a TRAF domain protein. Regulates the turnover of nucleotide-binding domain and leucine-rich repeat-containing (NLR) immune receptors SNC1 and RPS2. Loss of both MUSE13 and MUSE14 leads to enhanced pathogen resistance, NLR accumulation, and autoimmunity. In addition, MUSE13/14 physically interact with ATG6 and appear to regulate ATG6 ubiquitination and thus formation of autophagosomes.
TAIR Short Description  TRAF-like superfamily protein
TAIR Aliases  MUSE14, TRAF1a

1 Gene Rifs

1 Organism

12 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 5338  
Location: Chr5:17500376-17505713

Gene models - AT5G43560 AT5G43560

? Gene models

Transcripts: 2  Exons: 23  Introns: 21 

Overlapping Features

? Genome features that overlap coordinates of this Gene

16 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
TRF1A_ARATH TRF1A_ARATH-2 function Functions redundantly with TRAF1B in the regulation of plant immune response. Contributes to the turnover of the nucleotide-binding domain and leucine-rich repeat-containing (NB-LRR) immune receptors SNC1 and RPS2. May associate with an E3 ubiquitin-protein ligase complex, which modulates ubiquitination and subsequent degradation of NB-LRR immune sensors to maintain their homeostasis (PubMed:26867179). Functions redundantly with TRAF1B in the regulation of autophagosome formation. Required for SINAT1- and SINAT2-mediated ubiquitination and destabilization of ATG6. Functions as molecular adapter that helps to regulate autophagy by modulating ATG6 stability (PubMed:28351989).
TRF1A_ARATH TRF1A_ARATH-2 subcellular location Predominantly expressed in the cytoplasm. Associates with starvation-induced autophagosomes in continuous darkness.

2 Proteins

Function

Gene Ontology

cellular component
cytoplasm  ? ECO  
molecular function
protein histidine kinase binding  ? ECO  
biological process
innate immune response  ? ECO  
autophagosome organization  ? ECO  

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets