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Gene : AT5G39890 A. thaliana

DB identifier  ? AT5G39890 Secondary Identifier  ? locus:2178032
Brief Description  2-aminoethanethiol dioxygenase, putative (DUF1637)
TAIR Computational Description  2-aminoethanethiol dioxygenase, putative (DUF1637);(source:Araport11)
TAIR Curator Summary  Plant Cysteine Oxidase (PCO). Involved in controlling the stability of Group VII ethylene response factors (ERF-VIIs) via N-Arg/degron pathway through catalyzing the oxidation of their N-Cys for subsequent Arginyl-tRNA--protein transferase 1 (ATE1) mediated arginine installation.
TAIR Short Description  Protein of unknown function (DUF1637)
TAIR Aliases  HUP43, PCO2

1 Gene Rifs

1 Organism

13 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2001  
Location: Chr5:15974270-15976270

Gene models - AT5G39890 AT5G39890

? Gene models

Transcripts: 2  Exons: 9  Introns: 7 

Overlapping Features

? Genome features that overlap coordinates of this Gene

8 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
PCO2_ARATH developmental stage Expressed throughout development, with the highest expression in mature siliques and during seed germination.
PCO2_ARATH function Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (PubMed:24599061, PubMed:29848548, PubMed:33207269). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (PubMed:24599061, PubMed:29848548, PubMed:33207269). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (Probable) (PubMed:29848548). Not active on Cys located inside or at the C-terminus of a peptide (PubMed:24599061). Acts redundantly with PCO1 to repress the anaerobic response (PubMed:24599061).
PCO2_ARATH A0A1P8BCH5_ARATH similarity Belongs to the cysteine dioxygenase family.

2 Proteins

Function

Gene Ontology

cellular component
cytosol  ? ECO  
nucleus  ? ECO  
molecular function
cysteine dioxygenase activity  ? ECO  
iron ion binding  ? ECO  
biological process
detection of hypoxia  ? ECO  
response to hypoxia  ? ECO  
peptidyl-cysteine oxidation  ? ECO  
cellular response to hypoxia  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets