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encodes a homologue of the yeast (S. pombe) Mis12 (minichromosome instability) protein. MIS12 co-localizes with 180 bp repeats of centromeric DNA throughout the cell cycle with a similar pattern to AtCENH3/HTR12. Neither of these two proteins completely cover the 180 bp regions based on FISH analysis.
Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable). May play a role in the modulation of centromere during meiosis (PubMed:21695238).
Localizes at centromeric regions throughout the mitotic cell cycle. Co-localizes with CENH3 during the cell cycle, from interphase to anaphase (PubMed:16331414). Localized at centromeres in meiotic cells (PubMed:21695238).