Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
ASI1_ARATH | function | Collaboratively with AIPP1/EDM3 and EDM2, the AAE complex regulates alternative RNA processing (e.g. alternative splicing) and epigenetic silencing (e.g. H3K9me2) of intronic heterochromatin-containing genes as well as genic heterochromatin-containing genes by promoting distal 3' polyadenylation; may associate with intronic heterochromatin and bind gene transcripts to modulate polyadenylation (PubMed:24003136, PubMed:28808009, PubMed:33438356). Required to prevent promoter DNA hypermethylation and transcriptional silencing of some transgenes (PubMed:24003136). Plays a similar role to that of the histone H3K9 demethylase JMJ25/IBM1 in preventing CHG methylation in the bodies of numerous genes. RNA-binding protein that ensures the proper expression of JMJ25/IBM1 full-length transcript by associating with an intronic heterochromatic repeat element of JMJ25/IBM1 (PubMed:23934508, PubMed:24003136, PubMed:24404182). Modulates also transposable elements (TE) expression (PubMed:28808009, PubMed:33438356). Contributes to a unique mechanism to deal with the collateral effect of silencing intronic repeat elements (PubMed:23934508, PubMed:24003136, PubMed:24404182). |