Genomics
Overlapping Features
Genome features that overlap coordinates of this Gene
CDSs: 37, Exons: 21, Five Prime UTR: 1, mRNAs: 2, Three Prime UTR: 1, Transposable Element: 1, Transposon Fragment: 1
Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
RDM3_ARATH | function | Effector of RNA-directed DNA methylation (RdDM) triggered by small interfering RNAs (siRNAs, 24-nt RNAs). Functions as an adapter protein that binds scaffold transcripts generated by polymerase V and recruits AGO4 and AGO4-bound siRNAs to form an RdDM effector complex (PubMed:19343051, PubMed:19410546). Promotes the expression of 24-nt RNAs (PubMed:19343051). Required for the initial establishment of DNA methylation (PubMed:21150311). Together with AGO4, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci (PubMed:21738482). |
RDM3_ARATH | subcellular location | Localized at punctate nuclear foci. Colocalizes with AGO4 and polymerase V in the nucleoplasm. |
Function
Gene Ontology
cellular component | |
---|---|
nucleoplasm | ECO |
molecular function | |
chromatin binding | ECO |
DNA binding | ECO |
RNA binding | ECO |
biological process | |
DNA-templated transcription elongation | ECO |
regulation of transcription by RNA polymerase II | ECO |
gene silencing by siRNA-directed DNA methylation | ECO |
heterochromatin formation | ECO |
siRNA processing | ECO |
regulation of DNA-templated transcription elongation | ECO |
Interactions
Interaction Network
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