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Gene : ROT3 A. thaliana

DB identifier  ? AT4G36380 Secondary Identifier  ? locus:2115220
Name  ? ROTUNDIFOLIA 3 Brief Description  Cytochrome P450 superfamily protein
TAIR Computational Description  Cytochrome P450 superfamily protein;(source:Araport11)
TAIR Curator Summary  Encodes a cytochrome P-450 gene that is involved in leaf blade expansion by controlling polar cell expansion in the leaf length direction. Member of the CYP90C CYP450 family. ROT3 was shown to be involved in brassinosteroid biosynthesis, most likely in the conversion step of typhasterol (TY) to castasterone (CS). As 6-deoxo-CS was unable to restore the phenotype of rot3-1, it has been postulated that ROT3 might be specifically involved in the conversion of TY to CS in the C6-oxidation pathway of brassinolide. Recently, CYP90C1 was shown to catalyse the C-23 hydroxylation of several brassinosteroids (the enzyme has a broad specificity for 22-hydroxylated substrates).
TAIR Short Description  Cytochrome P450 superfamily protein
TAIR Aliases  ROT3

3 Gene Rifs

1 Organism

18 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 4980  
Location: Chr4:17187528-17192507 reverse strand

Gene models - ROT3 AT4G36380

? Gene models

Transcripts: 2  Exons: 17  Introns: 15 

Overlapping Features

? Genome features that overlap coordinates of this Gene

13 Child Features

0 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
C90C1_ARATH function Involved in brassinosteroid (BR) biosynthesis (PubMed:15703058, PubMed:17138693). Converts typhasterol (TY) to cathasterone (CS) and 6-deoxotyphasterol (6-deoxoTY) to 6-deoxocathasterone (6-deoxoCT) (PubMed:15703058). C-23 hydroxylase that converts directly (22S,24R)-22-hydroxy-5-alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo3DHT) and 6-deoxotyphasterol (6-deoxoTY), respectively (PubMed:17138693). These C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone (6-deoxoTE) (PubMed:17138693). Catalyzes also the conversion of cathasterone to teasterone (TE), (22S,24R)-22-hydroxyergost-4-en-3-one (22-OH-4-en-3-one) to (22R,23R)-22,23-dihydroxy-campest-4-en-3-one (22,23-diOH-4-en-3-one) and (22S)-22-hydroxycampesterol (22-OHCR) to (22R,23R)-22,23-dihydroxycampesterol (22,23-diOHCR) (PubMed:17138693). Required for the regulation of polar elongation of leaf cells (PubMed:10430960, PubMed:9694802). Required for the longitudinal elongation of floral organs (PubMed:10430960).
C90C1_ARATH pathway Plant hormone biosynthesis; brassinosteroid biosynthesis.
C90C1_ARATH similarity Belongs to the cytochrome P450 family.
C90C1_ARATH tissue specificity Widely expressed.

2 Proteins

Function

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets