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Gene : LTO1 A. thaliana

DB identifier  ? AT4G35760 Secondary Identifier  ? locus:2128028
Name  ? Lumen Thiol Oxidoreductase 1 Brief Description  NAD(P)H dehydrogenase (quinone)s
TAIR Computational Description  NAD(P)H dehydrogenase (quinone)s;(source:Araport11)
TAIR Curator Summary  Encodes a bimodular enzyme comprising an integral domain homologous to the catalytic subunit of mammalian vitamin K epoxide reductase (VKORC1, EC 1.1.4.1) that is fused to a soluble thioredoxin-like moiety. Using yeast microsomes as a recombinant system, it was shown that the VKORC1 domain of At4g35760 functions as a stringent naphthoquinone reductase, and that its reduced Trx-like partner can serve as its electron donor. Located in plastid. Required for the assembly of photosystem II. Can catalyze disulfide bond formation in vitro.
TAIR Short Description  NAD(P)H dehydrogenase (quinone)s
TAIR Aliases  LTO1

9 Gene Rifs

1 Organism

17 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2647  
Location: Chr4:16942031-16944677 reverse strand

Gene models - LTO1 AT4G35760

? Gene models

Transcripts: 2  Exons: 13  Introns: 11 

Overlapping Features

? Genome features that overlap coordinates of this Gene

10 Child Features

1 Cross References

0 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
LTO1_ARATH function Thiol-disulfide oxidoreductase catalyzing disulfide bond formation of chloroplast proteins and involved in redox regulation and photosynthetic electron transport. Required for the assembly of photosystem II (PSII) through the formation of disulfide bond in PSBO, a subunit of the PSII oxygen-evolving complex in the thylakoid lumen. Involved in the formation of disulfide bonds in the lumenal protein FKBP13. In vitro, reduces phylloquinone (vitamin K1) and menaquinone (vitamin K2) to their respective quinol. Cannot reduce phylloquinone epoxide to phylloquinone (PubMed:20626653, PubMed:21781282, PubMed:22209765, PubMed:23689258). Plays an important role in regulating the thylakoid lumen redox (PubMed:25412899).
A0A1P8B950_ARATH LTO1_ARATH similarity Belongs to the VKOR family.
LTO1_ARATH tissue specificity Expressed in cotyledons, rosette leaves, stems, cauline leaves and flowers.

2 Proteins

Function

Gene Ontology

cellular component
chloroplast thylakoid membrane  ? ECO  
plastid  ? ECO  
chloroplast  ? ECO  
molecular function
quinone binding  ? ECO  
NAD(P)H dehydrogenase (quinone) activity  ? ECO  
biological process
photosystem II assembly  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets