Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
ISU3_ARATH | function | Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S]proteins (PubMed:17417719). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3). In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S]proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). |
ISU3_ARATH | pathway | Cofactor biosynthesis; iron-sulfur cluster biosynthesis. |
ISU3_ARATH | similarity | Belongs to the NifU family. |
ISU3_ARATH | tissue specificity | Mostly expressed in flowers and pollen, and, to a lower extent, in leaves and roots. |
Function
Gene Ontology
cellular component | |
---|---|
cytosol | ECO |
mitochondrial matrix | ECO |
mitochondrion | ECO |
molecular function | |
structural molecule activity | ECO |
iron ion binding | ECO |
2 iron, 2 sulfur cluster binding | ECO |
biological process | |
iron-sulfur cluster assembly | ECO |
Interactions
Interaction Network
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