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Gene : DRB4 A. thaliana

DB identifier  ? AT3G62800 Secondary Identifier  ? locus:2081620
Name  ? double-stranded-RNA-binding protein 4 Brief Description  double-stranded-RNA-binding protein 4
TAIR Computational Description  double-stranded-RNA-binding protein 4;(source:Araport11)
TAIR Curator Summary  Encodes a nuclear dsRNA-binding protein DRB4 that interacts specifically with DCL4. May regulate DCL4 function and thereby affect miRNA biogenesis. Also has an impact on polymerase IV-dependent siRNA levels. DRB4 interacts with the P6 viral protein from Cauliflower mosaic virus and may be a target of viral silencing suppression.
TAIR Short Description  double-stranded-RNA-binding protein 4
TAIR Aliases  ATTIF3K1, DRB4

10 Gene Rifs

1 Organism

32 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 1987  
Location: Chr3:23225526-23227512 reverse strand

Gene models - DRB4 AT3G62800

? Gene models

Transcripts: 3  Exons: 13  Introns: 10 

Overlapping Features

? Genome features that overlap coordinates of this Gene

12 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
DRB4_ARATH DRB4_ARATH-2 function Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the trans-acting small interfering RNAs (ta-siRNAs) biogenesis by binding and assisting DICER-LIKE 4 (DCL4). Required for DCL4 activity. Required for the 21 nucleotide ta-siRNAs production of the TAS3 transcript in leaves but not in flowers. Plays an important role in silencing RNA of both DNA and RNA viruses. Involved with argonaute 7 (AGO7) and RDR6 in turnip crinkle virus (TCV) silencing. May not be directly involved in viral siRNA production. May stabilize the 21 nucleotide viral siRNAs and deliver them to the RISC complex. Targeted by the viral silencing suppressor (VSR) transactivator/viroplasmin (TAV) protein of the cauliflower mosaic virus (CaMV) that inactivates DRB4 function in RNA silencing. Probably not involved in the guide strand selection from RNA duplexes. Involved in leaf morphology through its function in ta-siRNA-mediated silencing.
DRB4_ARATH DRB4_ARATH-2 tissue specificity Expressed in roots, leaf vasculature, shoot apical meristem (SAM) and developing anthers.

2 Proteins

Function

Gene Ontology

cellular component
nucleus  ? ECO  
molecular function
double-stranded RNA binding  ? ECO  
biological process
defense response to virus  ? ECO  
miRNA processing  ? ECO  
RNAi-mediated antiviral immune response  ? ECO  
ta-siRNA processing  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets