Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
A0A654FJA0_ARATH A0A1I9LRW3_ARATH | function | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. |
A0A654FJA0_ARATH A0A1I9LRW3_ARATH | pathway | Protein modification; peptidyl-diphthamide biosynthesis. |
A0A654FJA0_ARATH A0A1I9LRW3_ARATH | similarity | Belongs to the DPH1/DPH2 family. DPH2 subfamily. |
Function
Gene Ontology
cellular component | |
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No terms in this category. | |
molecular function | |
iron-sulfur cluster binding | ECO |
2-(3-amino-3-carboxypropyl)histidine synthase activity | ECO |
metal ion binding | ECO |
biological process | |
protein histidyl modification to diphthamide | ECO |
Interactions
Interaction Network
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