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Gene : FIP37 A. thaliana

DB identifier  ? AT3G54170 Secondary Identifier  ? locus:2080275
Name  ? FKBP12 interacting protein 37 Brief Description  FKBP12 interacting protein 37
TAIR Computational Description  FKBP12 interacting protein 37;(source:Araport11)
TAIR Curator Summary  Encodes protein that binds FKBP12. This interaction is disrupted by FK506 but not by cyclosporin A.FIP37 is a core component of the M6A methyltransferase complex. Homozygous loss of function mutations are embryo lethal. In the shoot meristem FIP37 methylation targets include WUS and STM.
TAIR Short Description  FKBP12 interacting protein 37
TAIR Aliases  ATFIP37, FIP37

1 Gene Rifs

1 Organism

18 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2920  
Location: Chr3:20056664-20059583

Gene models - FIP37 AT3G54170

? Gene models

Transcripts: 1  Exons: 12  Introns: 11 

Overlapping Features

? Genome features that overlap coordinates of this Gene

13 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
FIP37_ARATH function Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:15047892, PubMed:28503769). Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769). N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:15047892, PubMed:28503769). Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especially in trichomes. May play a role in splicing events (PubMed:15047892).
FIP37_ARATH similarity Belongs to the fl(2)d family.
FIP37_ARATH subcellular location Nuclear with a speckled distribution pattern.
FIP37_ARATH tissue specificity Ubiquitously expressed with higher levels in primary and lateral roots, leaves, trichomes, and in pollen grains (at protein level).

1 Proteins

Function

Gene Ontology

cellular component
plasmodesma  ? ECO  
RNA N6-methyladenosine methyltransferase complex  ? ECO  
nucleus  ? ECO  
nuclear speck  ? ECO  
molecular function
No terms in this category.
biological process
RNA splicing  ? ECO  
mRNA processing  ? ECO  
RNA methylation  ? ECO  
meristem maintenance  ? ECO  
mRNA modification  ? ECO  
regulation of alternative mRNA splicing, via spliceosome  ? ECO  

Interactions

Interaction Network

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Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets