DB identifier | AT3G22590 | Secondary Identifier | locus:2077076 |
Name | PLANT HOMOLOGOUS TO PARAFIBROMIN | Brief Description | PLANT HOMOLOGOUS TO PARAFIBROMIN |
TAIR Computational Description | PLANT HOMOLOGOUS TO PARAFIBROMIN;(source:Araport11) |
TAIR Curator Summary | Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC). Member of PAF-C complex. |
TAIR Short Description | PLANT HOMOLOGOUS TO PARAFIBROMIN |
TAIR Aliases | CDC73, PHP |