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Gene : BZIP28 A. thaliana

DB identifier  ? AT3G10800 Secondary Identifier  ? locus:2103192
Brief Description  Basic-leucine zipper (bZIP) transcription factor family protein
TAIR Computational Description  Basic-leucine zipper (bZIP) transcription factor family protein;(source:Araport11)
TAIR Curator Summary  Encodes bZIP28, a putative membrane-tethered transcriptional factor. Up-regulated in response to heat; a bZIP28 null mutant has a heat-sensitive phenotype. bZIP28 has a similar domain structure to the mammalian ATF6 protein involved in the unfolded protein response (UPR), and shares a bZIP domain, transmembrane domain, and a canonical S1P cleavage site. The bZIP28 seems to be glycosylated in vivo. bZIP28 does not appear to be transcriptionally up-regulated by UPR-inducing tunicamycin (TM) treatment. But, the expression level of three UPR-related genes is reduced in TM-treated zip28 mutants relative to wild type seedlings. And several UPR genes are transcriptionally upregulated when an N-terminal portion of the bZIP28 protein is expressed using the 35S promoter. A myc:bZIP28 fusion protein appears to be cleaved, likely at a canonical S2 cleavage site, following a TM treatment or a DTT stress-inducing treatment, but not a salt treatment. A portion of the mGFP:bZIP28 protein present in root cells appears to translocate from the cytoplasm and ER to the nucleus following TM treatment. It is cleaved by S2P to allow translocation to the nucleus. The mRNA is cell-to-cell mobile.
TAIR Short Description  Basic-leucine zipper (bZIP) transcription factor family protein
TAIR Aliases  BZIP28

12 Gene Rifs

1 Organism

34 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 2454  
Location: Chr3:3379168-3381621

Gene models - BZIP28 AT3G10800

? Gene models

Transcripts: 1  Exons: 2  Introns: 1 

Overlapping Features

? Genome features that overlap coordinates of this Gene

3 Child Features

1 Cross References

1 Downstream Intergenic Region

0 Located Features

1 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
BZP28_ARATH function Transcriptional activator involved in ER stress responses. Functions as a stress sensor and transducer in ER stress signaling pathway. After proteolysis by SBT6.1 (S1P) and S2P, the N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones (PubMed:18156219, PubMed:18634751, PubMed:18849477, PubMed:20876872). Following ER stress, activates proteins involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth (PubMed:20876872).
BZP28_ARATH similarity Belongs to the bZIP family.
BZP28_ARATH subcellular location Translocates to the nucleus following heat shock or tunicamycin treatment (ER stress) (PubMed:18156219, PubMed:18634751, PubMed:18849477, PubMed:20876872, PubMed:22335396, PubMed:23558471, PubMed:23624714). Relocation of BZIP28 from ER to the nucleus occurs through the Golgi and is S2P-dependent (PubMed:20876872, PubMed:22335396, PubMed:23558471, PubMed:23624714).

1 Proteins

Function

Gene Ontology

cellular component
endoplasmic reticulum  ? ECO  
endoplasmic reticulum membrane  ? ECO  
nuclear envelope  ? ECO  
perinuclear region of cytoplasm  ? ECO  
nucleus  ? ECO  
nucleoplasm  ? ECO  
membrane  ? ECO  
Golgi membrane  ? ECO  
cytoplasm  ? ECO  
molecular function
DNA-binding transcription factor activity  ? ECO  
DNA binding  ? ECO  
biological process
response to heat  ? ECO  
response to endoplasmic reticulum stress  ? ECO  
endoplasmic reticulum unfolded protein response  ? ECO  
response to unfolded protein  ? ECO  

Interactions

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Expression

eFP Visualization

Data Source: BAR




Co-expression

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Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

9 Data Sets