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Gene : REF4 A. thaliana

DB identifier  ? AT2G48110 Secondary Identifier  ? locus:2039356
Name  ? REDUCED EPIDERMAL FLUORESCENCE 4 Brief Description  reduced epidermal fluorescence 4
TAIR Computational Description  reduced epidermal fluorescence 4;(source:Araport11)
TAIR Curator Summary  Encodes a novel protein of unknown function with homologs in non-seed plants. Sequence analysis predicts membrane spanning domains and a putative protein-protein interaction domain. Semi-dominant mutations display defects in phenylpropanoid accumulation suggesting a role in phenylpropanoid metabolism. It has been shown to physically associate with the conserved transcriptional coregulatory complex, Mediator, and is involved in the regulation of phenylpropanoid homeostasis. Required for expression of some dark-upregulated genes.
TAIR Short Description  reduced epidermal fluorescence 4
TAIR Aliases  MED33B, MED5B, REF4

3 Gene Rifs

1 Organism

15 Publications

0 Synonyms

Genomics

Genome feature

Region: gene ? Length: 6419  
Location: Chr2:19673293-19679711

Gene models - REF4 AT2G48110

? Gene models

Transcripts: 1  Exons: 14  Introns: 13 

Overlapping Features

? Genome features that overlap coordinates of this Gene

15 Child Features

0 Cross References

1 Downstream Intergenic Region

0 Located Features

0 Upstream Intergenic Region

Proteins

Curated comments from UniProt

Type Comment Proteins
MD33B_ARATH function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the repression of phenylpropanoid biosynthesis. May compete with MED33B for common binding partners or for occupancy in Mediator.
MD33B_ARATH similarity Belongs to the Mediator complex subunit 33 family.
MD33B_ARATH tissue specificity Ubiquitous.

1 Proteins

Function

Gene Ontology

cellular component
mediator complex  ? ECO  
membrane  ? ECO  
molecular function
No terms in this category.
biological process
phenylpropanoid metabolic process  ? ECO  
regulation of phenylpropanoid metabolic process  ? ECO  

Interactions

Interaction Network

Expression

eFP Visualization

Data Source: BAR




Co-expression

Querying ATTED Service...
Data Source: ATTED-II
Top N
LS: LS is a monotonic transformation (negative logit) of MR index. Larger LS indicates stronger co-expression.

 

Homology

Phytozome Homologs

Data Source: Phytozome


0 Homologues

 

Other

7 Data Sets