Proteins
Curated comments from UniProt
Type | Comment | Proteins |
---|---|---|
PCO4_ARATH PCO4_ARATH-2 | function | Catalyzes the oxidation of N-terminal cysteine residues (N-Cys), thus preparing the protein for N-end rule pathway-mediated proteasomal degradation, upstream of the N-end rule enzymes ATE1, ATE2 and PRT6 (Probable) (PubMed:28332493, PubMed:29848548, PubMed:32868422, PubMed:33207269). Controls the preparation of the group VII ethylene response factor (ERF-VII) proteins for degradation via the 26S proteasome N-end rule pathway (Probable) (PubMed:28332493, PubMed:29848548, PubMed:32868422, PubMed:33207269). Acts as an oxygen sensor that controls the stability of ERF-VII proteins, which are stabilized in flooding-induced hypoxia, and regulate transcriptional adaptation to these adverse conditions (PubMed:28332493, PubMed:29848548). |
A0A1P8B2S7_ARATH PCO4_ARATH PCO4_ARATH-2 A0A178VN46_ARATH | similarity | Belongs to the cysteine dioxygenase family. |
Function
Gene Ontology
cellular component | |
---|---|
nucleus | ECO |
cytoplasm | ECO |
molecular function | |
cysteine dioxygenase activity | ECO |
iron ion binding | ECO |
biological process | |
detection of hypoxia | ECO |
peptidyl-cysteine oxidation | ECO |
cellular response to hypoxia | ECO |
Interactions
Interaction Network
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